Strategy for ~14C-IabeIIng of a series of bis(heteroaryl)piperazines

摘要

Bis(heteroaryl)piperazines (BHAPs) have been a rich source of biologically active molecular entities and are related to a wide family of compounds with well-known pharmacological properties. A variety of analogues of BHAPs (such as: U-80493E) were synthesized and evaluated for their inhibition of human immunodeficiency virus typei reverse transcriptase. Sometimes replacement of the substituted aryl moiety with various aromatic systems provided bis (heteroaryl) piperazines that were10-100 fold more potent than U-80493E (for instance: Atevirdine).