EVALUATION OF [~11C]FORMYL CHLORIDE AS A CARBON-11 FORMYLATION AGENT: SYNTHESIS OF iV-(4-TOLYL)-[~11C] ORMAMIDE AS A MODEL REACTION

摘要

Formyl chloride was generated for the first time in 196.3 (1). This acid chloride of formic acid is stable below -60癈. At higher temperatures it dissociates spontaneously into carbon monoxide and hydrochloric acid. Recently, a new, highly efficient method for the preparation of formyl chloride at -78degC appeared in the literature (2): A complex made of hexachloroacetone (HCA) and two equivalents of triphenylphosphine (TPP) reacted at -78degC with formic acid to give formyl chloride, which was subsequently used in iV-formylation reactions.