SYNTHESIS, CRYSTAL STRUCTURE, AND CHARACTERIZATION OF TWO METAL-QUINOLONE COMPOUNDS

摘要

Two novel metal-quinolone compounds have been synthesized and characterized by analytical, spectroscopic, and X-ray diffraction methods. The crystal structure of both, (erxH(2))[FeCl4]Cl and (kinoH(2))[CuCl4].H2O, is presented and discussed (erxH(2) = doubly protonated form of enrofloxacin, kinoH(2) = doubly protonated form of the second quinolone). In both compounds, the hydrogen atom is bonded between the 4-keto oxygen O(1) and carboxylic oxygen O(11), thus preventing the bonding of the metal to this part of the molecule. Antimicrobial activities of metal-quinolone compounds were tested against different microorganisms. (C) 1997 Elsevier Science Inc. [References: 26]