Synthesis and DNA binding properties of a cationic 2,2 ': 6 ',2 ''-terpyridine, cobalt(II) complex containing an oligopeptide

摘要

The first example of DNA metallointercalator containing an oligopeptide moiety is presented. The ternary cobalt(II) complex [(DOTA)Co(II)(TPY)] (ClO4)(2) (DOTA=1,4,7,10-tetraaza-cyclododecane-2,9-dione, TPY=2, 2':6',2"-terpyridine) was found to be efficient in binding ct-DNA. The binding constant was determined by spectrophotometric titration. In vitro antitumor studies shows that this complex has significant antitumor activity. The single-crystal of a six coordinated oligopeptide cobalt(II) complex [Co(II)(DOTA)(2)](ClO4)(2) is also reported. The stabilities and species distributions of Co(II)-DOTA (1:1) and DOTA-Co(II)-TPY (1:1:1) systems were investigated by potentiometry titration. (C) 2003 Elsevier Science Inc. All rights reserved. [References: 19]