Synthesis of Novel Chiral C_2-symmetric Diaza-18-crown-6 Ether Derivatives and Their Enantioselective Recognition of Amino Acid Derivatives

摘要

New chiral diaza-18-crown-6 ether derivatives,5 and 6 were synthesized from(R)-(-)-2-amino-1-butanol.These chiral artificial receptors exhibit pronounced chiral recognition toward the enantiomers of L-and D-amino acid derivatives.The highest enantioselectivity was observed in the case of Trp-OMe centre dot HCl(K_D/K_L= 12.5).