Synthesis and Reactivity of Enaminones: A Facile Synthesis of Thiophene and 1,3,4-Thiadiazole Derivatives Incorporating a Thiazole Moiety

摘要

Several new heterocyclic compounds such as thiophene derivatives have been synthesized by the reactions of the versatile unreported 3-mercapto-2-(4-methyl-2-(tosylamino)thiazole-5-carbonyl)-3-phenylaminopropenal (7) with chloroacetonitrile, ethyl 2-bromoacetate, and 1-aryl-2-bromoethanone derivatives. Reaction of potassium salt intermediate 6 with hydrazonyl halides (14a-c) to afford 1,3,4-thiadiazole derivatives incorporating a thiazolemoiety has been described. All newly synthesized compounds were elucidated by considering the data of both elemental and spectral analysis.