Synthesis of Novel Tricyclic 1,5-Benzothiazepine Derivatives Bearing Quinoline Moiety via [2 + 2] Cycloaddition Reaction

摘要

1,5-Benzothiazepine is an important seven-membered heterocyclic ring system. It has attracted considerable attention to synthetic and medicinal chemists because of their broad spectrum of biological activities. It has been used as a calcium antagonist [1], antibacterial [2], anticancer drug[3,4], anticonvulsant, tranquilizer [5], and antidepressant[6]. For example, the drug diltiazem, intensively used in clinical practice, contains this system. It is well documented that pharmaceutical properties of such compounds are magnified when an additional heterocyclic is bound to the heptatomic nucleus [7-9]. To search for new potential useful 1,5-benzothiazepine derivatives, a great deal of work has been carried out on the synthesis of tricyclic 1,5-benzothiazepine derivatives in recent years [10].