Green multicomponent synthesis of 1,2-dihydro-pyrimido[1,2-a]-benzimidazole-3-carbonitrile

摘要

1,2-dihydro-pyrimido[1,2-a]benzimidazole-3-carbonitrile derivatives were synthesized via the three-component reaction of aldehyde, malonodinitrile and 2-aminobenzimidazole in water under microwave irradiation. The new protocol has the advantages of excellent yield, low cost, reduced environment impact, wide scope and convenient procedure.