3,4-dihydro-pyridine 1,2-a) substituted pyridine, 3,4, substituted dihydro-pyridine 1,2-a pyridine, preparation procedure and pharmaceutical synthesis containing pyridine

摘要

2, C12, C12, C12, C12, C12, C12, C12, C12, C12, C12, C12, C12, C12 single c3-c8, 1. Arilo, heaterilo, c1-c6-arilo, c1-c6-heterosexual, 1r3, R4 are h, R1 and R2, R3 and R4 are R3 and R4, Forman W; W is a '- (CH2) NB';a'ch=CH-CH2-B'；A'ch = ch - (CH 2) 2, group A; n is 3-10; X is CH2, O, s, B; R5 is C1-C12, cycloquilo c3-c8, 3-7 member heterosexual, arilo, heterosexual, C1-C6 tar; R6, R7, R8, R9, h, F, Cl, Br, I, cn, NH2, NH (C1-C6 tar),NH (C1-C6) 2, nh-arlo, nhr13, NO2, oh, SH, o-hc-c6, SOP asphalt C1-C8, P is 0-2, R6 and R7 Forman Q, q is y'cr15 = cr16cr17 = cr18-a, R6 and R9 Forman T, ES y'cr19 = cr20cr21 = cr22-e, y'n = cr20cr21 = N-E ';R10 is C1-C8, cycloquilo c3-c8, hetrarillo 3-7, arilo, heterosexual, c1-c6-arilo, R15, R16, R17, R18, h, Cl, Br, I, oh, CN, C1-C8, COOH, R19, R20, R21, R22 is h, F, Cl, Br, I, CN, oh, coal, C1-C8, COOH, which also refers to the preparation procedure. These compounds can be used to treat pain, urinary incontinence, Prut, dinitrus aureum, diarrhea