Reaction of benzohydroximinoyl chlorides and beta-(trifluoromethyl)acetylenic esters: Synthesis of regioisorneric (trifluoromethyl)isoxazolecarboxylate esters and oxime addition products

摘要

The triethylamine induced reaction of benzohydroximinoyl chlorides, precursors of nitrile oxides, with beta-trifluoromethylacetylenic esters gives rise to three products: 5-trifluoromethyl-4-isoxozolecarboxylate esters, regioisomeric 4-trifluoromethyl-5-isoxazolecarboxylate esters and an unexpected oxime 1,4-addition adduct. Product distribution is rationalized in terms of two competing reaction modes, either 1,4 addition of the oxime anion to the acetylenic ester or formation of the nitrile oxide followed by 1,3-dipolar cycloaddition. Anionic 1,4-addition of the oximinoyl chloride to the acetylenic ester is preferred at low temperatures, while nitrile oxide formation followed by cycloaddition is preferred at temperatures above 0 degreesC. Regioisomeric products from addition of nitrile oxides to various perfluoroalkylacetylenes are compared and assigned by C-13 NMR. [References: 41]