CONVENIENT SYNTHESIS OF 6-SUBSTITUTED-2-CHLORO-5,12-DIHYDRO-5-OXOBENZOXAZOLO[3,2-A]QUINOLINES AND N-ACYLATED-3-CHLORODIBENZ[B,E][1,4]OXAZEPIN-11(5H)-ONES

摘要

Convenient synthesis of variously substituted 2-chloro-5,12-dihydro-5-oxobenzoxazolo[3,2-a]quinolnes at the 6-position and N-acylated-3-chlorodibenz[b,e][1,4]oxazepin-11(5H)-ones are reported. The former compounds were obtained in 65-93% yield by simply heating N-acyl-4-chloro-N-(2-hydroxyphenyl)anthranilic acids in acetic anhydride for 4 hours, and the latter by heating sodium salt of N-acyl-4-chloro-N-(2-hydroxyphenyl)anthranilic acids with acetic anhydride. [References: 3]