Design and synthesis of 3-(l, 2,4,4a, 5, 6-hexahydro- pyrazino(l,2-a) quinolin-3-yl) -1- (4-methoxyphenyl) propane -l-one/1,4 dioxo2,3,4,4a, 5,6- hexahydro-lH-pyrazino (1,2-a) quinolines as Antialzheimer's agents

摘要

Alzheimer's disease is an age related and irreversible brain disorder that occurs gradually and results in memory loss, behavior and personality changes and a decline in thinking abilities. These losses are related to the breakdown of the connections between nerve cell in the brain and the eventual death of many of these cells. The course of this disease varies from person to person, as does the rate of decline in thinking. On an average patients with Alzheimer's disease live for 8 to 10 years after they are diagnosed, though the disease can last up to 20 years and eventually death occurs.2 Genetic and nongenetic factors are responsible for its development .the two abnormal structures in the brain amyloid plaques and neurofiblliary tangles are the hallmark of Alzheimer's disease.