Four-Component Reaction for Efficient Construction of Spiro[acenaphthylene-1,2-quinoline] skeleton

摘要

The four-component reactions of anilines, dialkyl acetylenedicarboxylate, acenaphthenequinone, and dimedone (or cyclohexane-1,3-dione) in acetic acid provided an efficient synthetic procedure for the functionalized spiro[acenaphthylene-1,2-quinoline] derivatives in good yields. This reaction has the advantages of using common starting material, mild reaction conditions, and operational simplicity.