Asymmetric vinylogous michael addition/cyclization cascade reaction for the construction of diversely structured spiro-oxindole skeletons

摘要

We present the first organocatalytic asymmetric vinylogous Michael/cyclization reaction of α,α-dicyanoalkenes with 3-alkylideneoxindoles. A series of diversely structured spiro-oxindole skeletons was smoothly delivered with excellent yields and stereoselectivity control (94-99% yields, >20:1 dr and 91 to >99% ee).