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首页> 外文期刊>Journal of exposure science & environmental epidemiology >Longitudinal assessment of chlorpyrifos exposure and effect biomarkers in adolescent Egyptian agricultural workers
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Longitudinal assessment of chlorpyrifos exposure and effect biomarkers in adolescent Egyptian agricultural workers

机译:埃及青年农业工人中毒死rif暴露和影响生物标志物的纵向评估

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摘要

Chlorpyrifos (CPF) is applied seasonally in Egypt by adolescent agricultural workers and the extent of occupational exposure and the potential for environmental CPF exposure in this population is poorly understood. Adolescent pesticide applicators (n=57; 12-21 years of age) and age-matched non-applicators (n=38) from the same villages were followed for 10 months in 2010, spanning pre-application through post-application. Eight urine and five blood samples were collected from participants within this time period. Blood acetylcholinesterase and butyrylcholinesterase (BChE; exposure/effect biomarker) and urine 3,5,6-trichloro-2-pyridinol (TCPy; exposure biomarker) were used to assess occupational CPF exposures in pesticide applicators and environmental exposures in non-applicators. Applicators demonstrated significantly higher TCPy concentration and BChE depression than non-applicators throughout CPF application. This difference persisted for 4-7 weeks after the cessation of agricultural spraying. However, both groups exhibited significantly elevated TCPy and depressed BChE, compared with their respective baseline. The peak TCPy levels during the spray season (95% confidence interval (CI)) for non-applicators and applicators reached 16.8 (9.87-28.5) and 137 (57.4-329) ug/g creatinine, respectively. BChE levels (95% CIs) during the spray were as follows: 1.47 (1.28-1.68) for non-applicators and 0.47 (0.24-0.94) U/ml for applicators. The longitudinal assessment of CPF biomarkers provided robust measures of exposure and effect throughout CPF application in adolescents and revealed significant exposures in both applicators and non-applicators. Biomarker data in the non-applicators, which mirrored that of the applicators, indicated that non-applicators received environmental CPF exposures. This suggests that similar exposures may occur in other residents of this region during periods of pesticide application.
机译:埃及的青年农业工人季节性使用毒死rif(CPF),对该人群的职业接触程度和环境CPF接触潜力了解得很少。 2010年对来自同一村庄的青春期农药施药者(n = 57; 12-21岁)和年龄匹配的未施药者(n = 38)进行了10个月的随访,涵盖从施用前到施用后的整个过程。在这段时间内从参与者那里收集了八份尿液和五份血液样本。血液乙酰胆碱酯酶和丁酰胆碱酯酶(BChE;暴露/效应生物标志物)和尿液3,5,6-三氯-2-吡啶醇(TCPy;暴露生物标志物)用于评估农药施用者的职业CPF暴露和非施用者的环境暴露。在整个CPF应用中,施药者均显示出TCPy浓度和BChE抑郁明显高于未施药者。停止农业喷洒后,这种差异持续了4-7周。然而,与各自的基线相比,两组均表现出明显升高的TCPy和降低的BChE。非施药者和施药者在喷雾季节的峰值TCPy水平(95%置信区间(CI))分别达到16.8(9.87-28.5)和137(57.4-329)ug / g肌酐。喷洒过程中的BChE水平(95%CI)如下:非施药者为1.47(1.28-1.68),施药者为0.47(0.24-0.94)U / ml。对CPF生物标志物的纵向评估提供了在青少年整个CPF应用过程中暴露和效果的有力指标,并显示了施药者和非施药者均存在大量暴露。非施药者中的生物标志物数据与施药者的情况相似,表明非施药者受到环境公积金暴露。这表明在农药施用期间,该地区的其他居民也可能发生类似的接触。

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