Effect of lactoferricin B and cecropin PI against enterotoxigenic Escherichia coli in vitro

摘要

Enterotoxigenic Escherichia coli (ETEC) is one of the most important causes of diarrhea in pigs, especially in postweaning piglets throughout the world. Natural products are the major source of leading compounds for drugs against pathogens. Antimicrobial peptides (AMPs) are small, endogenous, polycationic molecules that constitute a ubiquitous and significant component of innate immunity. In this study, we used two kinds of AMPs - lactoferricin B (Lfcin B) and cecropin PI (Cec PI) to against ETEC. The results showed that Lfcin B and Cec PI could effectively inhibit the growth of ETEC in vitro. Minimum Inhibition Concentration (MIC) and Minimum Effect Concentration (MEC) of Lfcin B are 0.8 and 1 |Xg/ml, respectively. MIC and MEC for Cec PI are the same, which is 0.6 (Xg/ml. The results suggested that Cec PI was more effective than Lfcin B but there was no statistically significant difference.