3-Amino-4-aminoximidofurazan derivatives: small molecules possessing antimicrobial and antibiofilm activityagainst Staphylococcus aureus and Pseudomonas aeruginosa

摘要

AimThe therapeutic treatment of microbial infections involving biofilm becomes quite challenging because of its increasing antibiotic resistance capacities. Towards this direction, in the present study we have evaluated the antibiofilm property of synthesized 3-amino-4-aminoximidofurazan compounds having polyamine skeleton. These derivatives were synthesized by incorporating furazan and biguanide moieties.