Sixth issue of the year 2010.

摘要

Alterations of BDNF signaling in major depression (MD) are supported by studies demonstrating decreased levels of the neurotrophin serum and plasma content in MD patients. Luisella Bocchio-Chiavetto and colleagues from Italy conducted a replication study and performed two meta-analyses on studies analysing serum and plasma BDNF levels in MD patients. The study included 489 patients/483 controls for the meta-analysis on serum and 161 patients/211 controls for that on plasma levels. The results provide evidence of alteration in MD of peripheral BDNF levels and support the importance of further investigation aiming to the identification of biomarkers for differential diagnosis and personalization of therapies in this disorder.