The Opposing Function of STAT3 as an Oncoprotein and Tumor Suppressor Is Dictated by the Expression Status of STAT3 beta in Esophageal Squamous Cell Carcinoma

摘要

Purpose: STAT3 is known to have both oncogenic and tumor suppressive effects, but the regulation of these opposing effects is elusive. We hypothesized that STAT3 beta, one of the two STAT3 isoforms, is the key determinant in this context.