Intraocular concentration of moxifloxacin after intracameral injection combined with presoaked intraocular lenses

摘要

Purpose To evaluate the impact of intraocular lens (IOL) moxifloxacin presoaking time on the intraocular concentration of moxifloxacin achieved after intracameral moxifloxacin injection. Setting Harlan Biotech Israel, Rehovot, Israel. Design Laboratory study Methods Sixty eyes of 30 rabbits were divided into 2 groups after crystalline lens evacuation. In Group A (30 eyes), hydrophilic acrylic IOLs presoaked for 15 minutes in 5 mg/mL moxifloxacin were implanted. In Group B (30 eyes), the same hydrophilic acrylic IOLs presoaked in the same solution for 24 hours were implanted. Intracameral injection of 100 mcg/0.1 moxifloxacin was performed at the end of surgery in both groups. Aqueous humor samples were obtained 2, 4, 6, 8, and 10 hours after IOL implantation and were analyzed by high-performance liquid chromatography to determine the antibiotic concentration. Results Group A achieved mean postoperative moxifloxacin concentrations of 18.60 mcg/mL ± 8.80 (SD), 4.08 ± 6.03 mcg/mL, 1.50 ± 0.75 mcg/mL, 0.21 ± 0.09 mcg/mL, and 0.12 ± 0.04 mcg/mL at 2, 4, 6, 8, and 10 hours, respectively. Group B achieved mean moxifloxacin concentrations of 17.25 ± 6.27 mcg/mL, 9.46 ± 2.22 mcg/mL, 6.26 ± 1.22 mcg/mL, 4.34 ± 0.42 mcg/mL, and 3.62 ± 1.02 mcg/mL, respectively. Moxifloxacin concentrations at 6, 8, and 10 hours were statistically significantly higher in Group B than in Group A (all P <.0001). Conclusions Combining intracameral moxifloxacin injection with implantation of moxifloxacin-presoaked hydrophilic acrylic IOLs yielded high intraocular concentrations of moxifloxacin. Higher concentrations were found with longer presoaking. Financial Disclosure No author has a financial or proprietary interest in any material or method mentioned.