Modelling the Release of Moxifloxacin from Plasma Grafted Intraocular Lenses with Rotational Symmetric Numerical Framework

摘要

A rotational symmetric finite element model is constructed to simulate the release of moxifloxacin from different types of plasma-grafted intraocular lenses, utilizing general discontinuous boundary conditions to describe the interface between lens and outside medium. Such boundary conditions allow for the modelling of partitioning and interfacial mass transfer resistance. Due to its rotational symmetry, the shape of the optical part of the intraocular lens is fully taken into account. Two types of polyacrylates were plasma-grafted to the intraocular lens to act as barriers for the release of the loaded drug. Simulations are carried out and compared to release experiments to infer drug-material properties, which is crucial for optimising therapeutic effects.