A new leaving group in nucleophilic aromatic substitution reactions (S_NAr)

摘要

Nucleophilic aromatic substitution of a 2,4-dinitrophenyl substituted pyrazole 1 with primary amines leads to substitution of the pyrazolo substituent. In these nucleophilic aromatic substitution reactions (S_NAr), 5-amino-1H-4- pyrazolecarbonitrile (3) acts as a new leaving group.