Three-component one-pot synthesis of unsymmetrical 1,4-dihydropyridine derivatives in aqueous media

摘要

A series of methyl ethyl 2,6-dimethyl-4-substituted-1,4-dihydropyridine-3,5-dicarboxylates were synthesised by the three-component reaction of aldehydes, ethyl acetoacetate and methyl β-aminocrotonate in the presence of triethylbenzylammonium chloride (TEBAC) in aqueous medium. This method has the advantage of good yields.