水介质中双(1,4-二氢吡啶)衍生物的合成

摘要

A series of functionalized bis(1,4-dihydropyridine)derivatives were synthesized via a multicomponent reaction of p-phe-nylenedialdehyde,1,3-dicarbonyl compounds and ammonium acetate in the presence of triethylbenzylammonium chloride(TEBAC) in aqueous medium. The structures of all products were identified by their IR and 1 H NMR analysis. This protocol had the advanta-ges of simple operation,high yields,and environmentally friendliness.%水介质中在苄基三乙基氯化铵(TEBAC)催化下,利用对苯二甲醛与1,3-二羰基化合物及醋酸铵的多组分反应合成了一系列官能团化双(1,4-二氢吡啶)衍生物.产物的结构通过红外光谱和核磁共振氢谱确定.该方法具有操作简单、产率高、环境友好等特点,为新型1,4-二氢吡啶衍生物的合成提供了一条绿色合成的途径.