First Soluble Multipolymer MPEG-Supported Liquid-Phase Convergent Synthesis of Tripeptide Fmoc-GlyVal-GlyOH

摘要

Polymer supported solid-phase organic synthesis has been widely used in combinatorial chemistry.The preparation of peptides was realized only after the application of the technique to solid-phase peptide synthesis(SPPS),which was first developed by Merrifield.However,the heterogeneous nature of such synthesis presents many problems associated with insoluble polymers,including nonlinear kinetic behavior,unequal distribution or access to the chemical reaction,solvent problems associated with the nature of the support,and synthetic difficulties in transferring the standard organic to the solid phase.