Construction of a 3-Amino-2-pyridone Library by Ring-Closing Metathesis of a-Amino Acrylamide

摘要

Over the past decade,the olefin metathesis reaction has become one of the most important methods for carbon-carbon double-bond formation in organic synthesis.In particular,ring-closing olefin metathesis (RCM) has been widely applied as a key step in constructing cyclic olefins of many sizes containing ether,ester,amide,or amino groups in several total syntheses of complex natural products.