Solid-Phase Synthesis of 2,3,5-Trisubstituted 4H-Imidazolones

摘要

The rapid synthesis of large organic compound collections by combinatorial methods using solid-phase approaches continues to be a promising strategy for the discovery of new pharmaceutical lead compounds. The focus of this field of research, which initially involved the synthesis of peptides and oligonucleotides, is now on the synthesis of small organic molecules on the solid phase. Heterocycles, such as benzo-diazepines, hydantoins, pyrrolidines, bicyclic guanidines, have received special attention in combinatorial synthesis because of their biologically relevant properties. This strategy has permitted the rapid synthesis of large numbers of heterocyclic compounds in a short time period, facilitating their use in high-throughput screening.