Solvent-fre three-component condensation reaction of aromatic ketones with aliphatic amines and formaldehyde

摘要

A solvent-free procedure for the synthesis of several 1-aryl-2-(dialkylaminomethyl)-2-en-1-ones 3 (a-e) and 4 (a-e) is reported. Reaction of arylmethyl ketones with fromaldehyde and dialkylamines, such as diethyl- or dibutylamines at room temperature in silica gel produce 3 and 4 with moderate yields.