Three-component Reaction of Aromatic Aldehyde,Malononitrile and Aliphatic Amine Leading to Different Pyridine Derivatives

摘要

The three-component reaction of aromatic aldehyde,malononitrile and aliphatic amine in a mixed solvent of methanol and water exhibited very interesting molecular diversity and gave the derivatives of polysubstituted N-methyldihydropyridines,2-dialkylaminopyridines and 2-methoxypyridines as main products according to the structure of aliphatic amines used.