Formation of an imidosuccinimide by cyclisation of a sterically hindered beta-cyanoester with the lithium salt of a primary amine

摘要

The reaction of beta-cyanoester 1 with a two-fold excess of the lithium salt of homoveratrylamine in THF at 0 degrees C to room temperature affords the imidosuccinimide 3, which undergoes derivation to the succinimide monooxime 4 by treatment with m-chloroperoxybenzoic acid. [References: 17]