Efavirenz Inhibits the Human Ether-A-Go-Go Related Current (hERG) and Induces QT Interval Prolongation in CYP2B6*6*6 Allele Carriers

Abdelhady Ahmed M.; Shugg Tyler; Thong Nancy; Lu Jessica Bo Li; Kreutz Yvonne; Jaynes Heather A.; Robarge Jason D.; Tisdale James E.; Desta Zeruesenay; Overholser Brian R.

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Efavirenz Inhibits the Human Ether-A-Go-Go Related Current (hERG) and Induces QT Interval Prolongation in CYP2B666 Allele Carriers

机译：Efavirenz抑制人以太Go-Go相关电流（hERG）并诱导CYP2B6 * 6 * 6等位基因载体的QT间隔延长

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Efavirenz Induced QTc Interval Prolongation

机译：Efavirenz诱导的QTc间隔延长

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来源
《Journal of cardiovascular electrophysiology 》 |2016年第10期| 共8页
作者
Abdelhady Ahmed M.; Shugg Tyler; Thong Nancy; Lu Jessica Bo Li; Kreutz Yvonne; Jaynes Heather A.; Robarge Jason D.; Tisdale James E.; Desta Zeruesenay; Overholser Brian R.;
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正文语种 eng
中图分类人体生理学 ;
关键词
efavirenz; hERG; QTc; QTc interval prolongation; torsade de pointes;

机译：efavirenz;hERG;QTc;QTc间隔延长;尖端扭转型室速;

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1. Efavirenz Inhibits the Human Ether-A-Go-Go Related Current (hERG) and Induces QT Interval Prolongation in CYP2B6*6*6 Allele Carriers [J] . Abdelhady Ahmed M., Shugg Tyler, Thong Nancy, Journal of cardiovascular electrophysiology . 2016 ,第10期

机译：Efavirenz抑制人以太Go-Go相关电流（hERG）并诱导CYP2B6 * 6 * 6等位基因载体的QT间隔延长
2. Effects of probucol, a typical hERG expression inhibitor, on in vivo QT interval prolongation in conscious dogs [J] . NogawaH., KawaiT., YajimaM., European Journal of Pharmacology: An International Journal . 2013 ,第1a3期

机译：普罗布考（一种典型的hERG表达抑制剂）对清醒犬体内QT间隔延长的影响
3. Effects of probucol, a typical hERG expression inhibitor, on in vivo QT interval prolongation in conscious dogs [J] . NogawaH., KawaiT., YajimaM., European Journal of Pharmacology: An International Journal . 2013 ,第1a3期

机译：普罗布考（一种典型的hERG表达抑制剂）对清醒犬体内QT间隔延长的影响
4. Drug-induced QT interval prolongation - regulatory guidance and perspectives on hERG channel studies [C] . Rashmi R Shah symposium on The hERG cardiac potassium channel: structure, function, and long QT syndrome . 2005

机译：药物诱导的QT间隔延长 - 监管指导和HERG渠道研究的观点
5. Potential mechanisms for drug-induced prolongation of QT interval and genesis of torsades de pointes evaluated in the failing rabbit heart. [D] . Kijtawornrat, Anusak. 2007

机译：在衰竭的心脏中评估了药物引起的QT间隔延长和扭转性扭转的潜在机制。
6. Efavirenz inhibits the human ether-a-go-go related current (hERG) and induces QT interval prolongation in CYP2B6*6*6 allele carriers [O] . Ahmed M. Abdelhady, Tyler Shugg, Nancy Thong, -1

机译：Efavirenz抑制人与人有关的电流（hERG）并诱导CYP2B6 * 6 * 6等位基因携带者QT间期延长
7. Hydroxyzine, a First Generation H1-Receptor Antagonist, Inhibits Human Ether-a-go-go–Related Gene (HERG) Current and Causes Syncope in a Patient With the HERG Mutation [O] . Tomoko Sakaguchi, Hideki Itoh, Wei-Guang Ding, 2008

机译：羟嗪，第一代H1受体拮抗剂，抑制人类ether-A-GO-go相关基因（HERG）电流，并在患者的HERG基因突变导致晕厥
8. Q-T-Interval in Relatie tot Totale, Cardiovasculaire en IschaemischeHartziektesterfte: Een Prospektieve Studie onder Amsterdamse Ambtenaren (QT-Interval Prolongation Predicts Cardiovascular Mortality in the General Population) [R] . Meppelink, P. 1990

机译：Q-T-Interval in Relatie tot Totale，Cardiovasculaire en IschaemischeHartziektesterfte：Een prospektieve studie onder amsterdamse ambtenaren（QT-Interval延长预测一般人群中的心血管死亡率）

Efavirenz Inhibits the Human Ether-A-Go-Go Related Current (hERG) and Induces QT Interval Prolongation in CYP2B6*6*6 Allele Carriers

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Efavirenz Inhibits the Human Ether-A-Go-Go Related Current (hERG) and Induces QT Interval Prolongation in CYP2B666 Allele Carriers