Commentary: G × e in child psychiatry and psychology: A broadening of the scope of enquiry as prompted by Munafo et al. (2014)

摘要

The accompanying Practitioner Review by Munafo et al. (2014) presents two main arguments: (1) that there are few (if any) examples of G x E in psychiatry so it cannot aid gene discovery, and (2) that genome-wide association studies (GWAS) are already yielding important findings. With respect to the supposed weakness of G x E research, they fail to mention any of the substantial body of evidence in support of G x E - see various chapters in Dodge and Rutter (2011). Any serious attempt to dismiss G x E must address the arguments and evidence in support of G x E. That is not done here.