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Sterol transport in yeast and the oxysterol binding protein homologue (OSH) family

机译:酵母中的甾醇转运和氧固醇结合蛋白同源物(OSH)家族

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摘要

Sterols such as cholesterol are a significant component of eukaryotic cellular membranes, and their unique physical properties influence a wide variety of membrane processes. It is known that the concentration of sterol within the membrane varies widely between organelles, and that the cell actively maintains this distribution through various transport processes. Vesicular pathways such as secretion or endocytosis may account for this traffic, but increasing evidence highlights the importance of nonvesicular routes as well. The structure of an oxysterol-binding protein homologue (OSH) in yeast (Osh4p/Kes1p) has recently been solved, identifying it as a sterol binding protein, and there is evidence consistent with the role of a cytoplasmic, nonvesicular sterol transporter. Yeast have seven such proteins, which appear to have distinct but overlapping functions with regard to maintaining intracellular sterol distribution and homeostasis. Control of sterol distribution can have far-reaching effects on membrane-related functions, and Osh proteins have been implicated in a variety of processes such as secretory vesicle budding from the Golgi and establishment of cell polarity. This review summarizes the current body of knowledge regarding this family and its potential functions, placing it in the context of known and hypothesized pathways of sterol transport in yeast. Published by Elsevier B.V.
机译:胆固醇等甾醇是真核细胞膜的重要组成部分,其独特的物理性质会影响多种膜过程。已知膜内固醇的浓度在细胞器之间变化很大,并且细胞通过各种转运过程积极地维持这种分布。诸如分泌或胞吞作用之类的囊泡途径可能是这种流量的原因,但是越来越多的证据也凸显了非囊泡途径的重要性。酵母中的氧固醇结合蛋白同源物(OSH)的结构(Osh4p / Kes1p)最近已得到解决,将其鉴定为固醇结合蛋白,并且有证据表明其与细胞质非囊泡固醇转运蛋白的作用一致。酵母具有七个这样的蛋白质,就维持细胞内固醇分布和体内稳态而言,它们似乎具有独特但重叠的功能。固醇分布的控制可能对膜相关功能具有深远的影响,Osh蛋白已经参与了多种过程,例如高尔基体分泌的囊泡出芽和细胞极性的建立。这篇综述总结了有关该家族及其潜在功能的当前知识体系,并将其置于酵母中固醇转运的已知和假设途径的背景下。由Elsevier B.V.发布

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