首页> 外文期刊>Journal of biomedical materials research, Part A >The innovative application of a novel bone adhesive for facial fracture osteosynthesis-in vitro and in vivo results.
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The innovative application of a novel bone adhesive for facial fracture osteosynthesis-in vitro and in vivo results.

机译:新型骨粘合剂在面部和骨折的体内外合成中的创新应用。

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摘要

This study evaluates a novel adhesive fixation technique to affix cortical bone fragments to osteosynthesis plates using common PMMA cement. This technique utilizes a new amphiphilic bone bonding agent adhering with both hydrophilic bone and hydrophobic PMMA cement. After in vitro biomechanical testing of the bonding strength with explanted bovine and rabbit calvarian bone samples, osteosynthesis plates with screw holes of 1.3 and 1.5 mm were placed on the cranial bone of New Zealand white rabbits and the bond strength of these plates was determined through tension tests. In vitro bond strengths of 19.8-26.5 MPa were obtained. Control samples, prepared without a bone bonding agent, exhibited bone bonding strengths <0.2 MPa. In vivo respective bond strengths at the cranium of the white rabbits were 2.5-4.1 MPa 2 weeks post surgery and 1.9-2.5 MPa 12 weeks after implantation. This new innovative fixation method can be envisioned for cases in which conventional fixation techniques of screws and plates are insufficient or not possible due to the bone or trauma conditions. The observed bonding strengths support implementing this technique in nonload bearing regions, such as the central midface or frontal sinus, facilitating immobilization until bone reunion is complete.
机译:这项研究评估了一种新颖的粘合剂固定技术,可使用普通的PMMA胶粘剂将皮质骨碎片固定在骨合成板上。该技术利用了一种新的两亲性骨结合剂,该两性骨结合剂与亲水性骨和疏水性PMMA水泥粘合。在对与牛和兔颅骨外植体的结合强度进行体外生物力学测试后,将具有1.3和1.5 mm螺孔的骨合成板放置在新西兰白兔的颅骨上,并通过拉力确定这些板的结合强度测试。获得了19.8-26.5 MPa的体外粘结强度。不含骨结合剂的对照样品的骨结合强度<0.2 MPa。在白兔的颅骨上的体内各自的结合强度是术后2周的2.5-4.1MPa和植入后12周的1.9-2.5MPa。可以设想这种新的创新固定方法,用于因骨头或创伤情况而导致螺钉和板的常规固定技术不足或无法实现的情况。观察到的粘结强度支持在非承重区域(例如中央中表面或额窦)实施该技术,从而有助于固定直至骨团聚完成。

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