Design of a Porous Chitosan Based Matrix Tablet as Carrier for Controlled Delivery of Diltiazem Hydrochloride

摘要

The aim of present work was to develop a porous controlled delivery system of Diltiazem hydrochloride (DTH) as an alternative for conventional tablets. The pores were induced into these tablets by directly compressing the tablet excipients with a sublimable material, camphor which was eventually sublimated leaving pores. Aqueous drug solution of DTH was spiked on the tablet surface. The maximum volume of drug solution absorbed was limited, revealing that these porous carriers were ideal for low dosed formulations. Precompression parameters of the powder mixes to make the porous tablets and post compression parameters of the tablets were assessed and found to be within prescribed limits. The influence of pore forming agent on properties of tablets were investigated. It was observed that an increase in pore forming agent leads to decrease in hardness and disintegration time of porous tablets. In vitro release data showed that drug release was significantly affected by concentration of pore forming agent present in the respective batches of tablets. The mechanism of drug release with all the formulations was dominantly diffusion and followed zero order kinetics. The formulations were found to be stable up to 3 months when tested for stability at 40 degrees C/75% RH. The prepared porous chitosan based matrix tablet released DTH for 10 h, signaling to consider as an effective low dose drug delivery candidate.