PREPARATION AND STRUCTURE-ACTIVITY RELATIONSHIPS OF 4-SUBSTITUTED AMINO-2-METHYLPYRIDO[3,4-D]PYRIMIDINES AS CYTOKININ ANALOGS

摘要

Various 4-substituted amino derivatives of 2-methylpyrido[3,4-d]pyrimidine were prepared to investigate their structure-cytokinin activity relationships. Both an Amaranthus betacyanin and a lettuce seed germination bioassay revealed that most anilino and some alkylamino derivatives were active, whereas benzylamino derivatives were inactive, indicating that the new cytokinin analogs differ from N-6-adenines in their substituent effects on the activity. The most active was a m-fluoroanilino derivative, which was as potent as N-6-benzyladenine in a tobacco callus bioassay. 2-Alkyl substituents smaller or larger than a methyl group reduced the activity.