Hepatitis B and C viruses infection, lifestyle and genetic polymorphisms as risk factors for hepatocellular carcinoma in haimen, china.

摘要

A case-control study was carried out to investigate the impact of factors including virus infection, aflatoxin B1, microcystins, smoking / drinking and dietary habits as well as genetic polymorphisms of aldehyde dehydrogenase 2 (ALDH2) and cytochrome P4502E1 (CYP2E1), on susceptibility to hepatocellular carcinoma (HCC) in Haimen, China. A total of 248 patients with HCC and 248 sex-, age- and residence-matched population-based controls were recruited into the study. Virus infection, and ALDH2 and CYP2E1 gene polymorphisms were assessed in 134 paired cases and controls. By univariate analysis, hepatitis B virus (HBV) infection (odds ratio [OR] = 9.75; 95% confidence interval [CI] = 4.71 - 20.2), history of intravenous injection (OR = 1.50; 95%CI = 1.02 - 2.22), average income (OR = 0.63; 95%CI = 0.43 - 0.92), frequent intake of foods rich in protein, e.g., egg (OR = 0.6; 95%CI = 0.42 - 0.87), chicken (OR = 0.53; 95%CI = 0.35 - 0.79), pork (OR = 0.67; 95%CI = 0.46 - 0.98) and fresh fish (OR = 0.58; 95%CI