METHOD FOR PREDICTION OF RISK OF DEVELOPMENT OF HEPATOCELLULAR CARCINOMA IN PATIENTS WITH CHRONIC HEPATITIS C

摘要

FIELD: medicine.;SUBSTANCE: invention relates to medicine and relates to a method for predicting the risk of developing hepatocellular carcinoma in patients with chronic hepatitis C. The essence of the method lies in the fact that a set of indicators of the level of alpha-fetoprotein, glypican-3 and ostepontin in venous blood is determined. The threshold value is pre-calculated for each tumor marker. The result is compared with the threshold values for alpha-fetoprotein (16.0 ng / ml); for osteopontin (80.0 ng / ml); for glypican-3 (1.0 ng / ml). The risk of developing the disease is predicted according to the following algorithm: if the level of three detectable tumor markers is less than or equal to the threshold value, there is no risk of developing hepatocellular carcinoma; if the threshold value of one of the tumor markers is exceeded, the risk of developing the disease is low; when the threshold value of two tumor markers is exceeded, the risk of developing the disease is high; when the threshold value of three detectable tumor markers is exceeded, the absolute risk of developing hepatocellular carcinoma is predicted.;EFFECT: use of the method allows predicting with high accuracy the risk of developing hepatocellular carcinoma in patients with chronic hepatitis C.;1 cl, 1 dwg, 3 ex, 3 tbl