Conversion from depression to bipolar disorder in a cohort of young people in England, 1999-2011: A national record linkage study

摘要

Objective: To estimate the conversion rate from unipolar depression (ICD10 codes F32-F33) to bipolar disorder (BP) (ICD10 codes F31) in an English national cohort. It was hypothesised that early-onset BP (age < 18 years) is a more severe form of the disorder, with a more rapid, and higher rate of conversion from depression to BR