Operation of Spatiotemporal Patterns Stored in Living Neuronal Networks Cultured on a Microelectrode Array

摘要

We provided further insights into "biological" pattern detection. In dissociated neurons, we induced synaptic potentiation, which corresponds to an increase in the weight of connection between neurons of an artificial neural network. We also performed a kind of primary "operation" for a spatiotemporal pattern stored in a cultured neural network. Results suggest that small-scaled living neuronal networks enable to carry out information processing such as pattern detection. Information processing during pattern manipulation is analyzed using living neuronal networks interacting with artificial electric devices. The goal is an artificial living system in which the neural network recognizes environmental patterns around it and controls its growth conditions. The system is useful both in the context of new applied bioelectro technology and basic neuroscience research.