Network structure reconstruction using packets of spikes in cultured neuronal networks coupled to microelectrode arrays

摘要

Reconstructing accurately the structure of neural networks from biological data is essential for the analysis of simultaneous recordings from many neurons, and, in turn, for the understanding of neural codes and the design of neural prostheses. Classical techniques are generally based on cross-correlations and cannot reconstruct unambiguously the network structure. Recently, we have proposed a method for which there is one-to-one correspondence between statistical properties of packets of spikes (or avalanches) and the network structure, but this mapping was only proven for simpler neuronal model. In the following, we show using numerical simulation of the Izhikevich model that the proposed method is general, and is particularly well-fitted for the analysis of neural activity recorded from cultured neuronal networks coupled to microelectrode arrays.