Synthesis and antiviral activity of 2'-deoxy-2'-fluoro-2'-C-methyl purine nucleosides as inhibitors of hepatitis C virus RNA replication.

Clark JL; Mason JC; Hollecker L; Stuyver LJ; Tharnish PM; McBrayer TR; Otto MJ; Furman PA; Schinazi RF; Watanabe KA

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Synthesis and antiviral activity of 2'-deoxy-2'-fluoro-2'-C-methyl purine nucleosides as inhibitors of hepatitis C virus RNA replication.

机译：2'-脱氧-2'-氟-2'-C-甲基嘌呤核苷作为丙型肝炎病毒RNA复制抑制剂的合成及其抗病毒活性。

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A series of purine nucleosides containing the 2'-deoxy-2'-fluoro-2'-C-methylribofuranosyl moiety were synthesized and evaluated as potential inhibitors of the hepatitis C virus in vitro. Of the nucleosides that were synthesized, only those possessing a 2-amino group on the purine base reduced the levels of HCV RNA in a subgenomic replicon assay.

机译：合成了一系列含有2'-脱氧-2'-氟-2'-C-甲基核呋喃呋喃糖基部分的嘌呤核苷，并作为体外丙型肝炎病毒的潜在抑制剂进行了评估。在合成的核苷中，只有在嘌呤碱基上具有2-氨基的核苷才能在亚基因组复制子测定中降低HCV RNA的水平。

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来源
《Bioorganic and Medicinal Chemistry Letters 》 |2006年第6期| 共4页
作者
Clark JL; Mason JC; Hollecker L; Stuyver LJ; Tharnish PM; McBrayer TR; Otto MJ; Furman PA; Schinazi RF; Watanabe KA;
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正文语种 eng
中图分类药学 ; 生物化学 ;
关键词
Antiviral Agents; Hepacivirus; Purine Nucleosides; RNA; Viral; Virus Replication; 抗病毒药; 嘌呤核苷类; RNA; 病毒; 病毒复制;

机译：Antiviral Agents;Hepacivirus;Purine Nucleosides;RNA;Viral;Virus Replication;抗病毒药;嘌呤核苷类;RNA;病毒;病毒复制;

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1. Synthesis and antiviral activity of 2'-deoxy-2'-fluoro-2'-C-methyl purine nucleosides as inhibitors of hepatitis C virus RNA replication. [J] . Clark JL, Mason JC, Hollecker L, Bioorganic and Medicinal Chemistry Letters . 2006 ,第6期

机译：2'-脱氧-2'-氟-2'-C-甲基嘌呤核苷作为丙型肝炎病毒RNA复制抑制剂的合成及其抗病毒活性。
2. The Mechanism of Action of {beta}-D-2'-Deoxy-2'-Fluoro-2'-C-Methylcytidine Involves a Second Metabolic Pathway Leading to {beta}-D-2'-Deoxy-2'-Fluoro-2'-C-Methyluridine 5'-Triphosphate, a Potent Inhibitor of the Hepatitis C Virus RNA-Dependent RNA Po [J] . Murakami E, Niu C, Bao H, Antimicrobial agents and chemotherapy. . 2008 ,第2期

机译：β-D-2'-脱氧-2'-氟-2'-C-甲基胞苷的作用机理涉及导致β-D-2'-脱氧-2'-氟-的第二种代谢途径。 2'-C-甲基尿苷5'-三磷酸，丙型肝炎病毒RNA依赖性RNA Po的有效抑制剂
3. Synthesis and anti-HCV activity of a new 2'-deoxy-2'-fluoro-2'-C-methyl nucleoside analogue. [J] . Hu W, Wang P, Song C, Bioorganic and Medicinal Chemistry Letters . 2010 ,第24期

机译：新的2'-脱氧-2'-氟-2'-C-甲基核苷类似物的合成和抗HCV活性。
4. The Synthesis of an Antiviral Fluorinated Purine Nucleoside: 3'-α-Fluoro-2',3'-dideoxyguanosine [C] . Kunisuke Izawa, rnTakayoshi Torii, Tomoyuki Onishi, Current fluoroorganic chemistry : New synthetic directions, technologies, materials, and biological applications . 2005

机译：抗病毒氟化嘌呤核苷的合成：3'-α-氟-2'，3'-二脱氧鸟苷
5. Part I: Synthesis of 2'-Fluoro-2',3'-Dideoxynucleosides as Inhibitors of Hepatitis C Virus RNA-Dependent RNA Polymerase. Part II: Synthesis of Cyclobutyl Phosphonate and Phosphoramidate Prodrugs for Inhibition of HIV Reverse Transcriptase [D] . Neuman, Annette Welty 2013

机译：第一部分：2'-Fluoro-2'，3'-Dideoxynucleosides的合成作为丙型肝炎病毒RNA依赖性RNA聚合酶的抑制剂。第二部分：抑制HIV逆转录酶的膦酸环丁酯和氨基磷酸酯前药的合成
6. The Mechanism of Action of β-d-2′-Deoxy-2′-Fluoro-2′-C-Methylcytidine Involves a Second Metabolic Pathway Leading to β-d-2′-Deoxy-2′-Fluoro-2′-C-Methyluridine 5′-Triphosphate a Potent Inhibitor of the Hepatitis C Virus RNA-Dependent RNA Polymerase [O] . Eisuke Murakami, Congrong Niu, Haiying Bao, 2008

机译：β-d-2-Deoxy-2-Fluoro-2-C-甲基胞苷的作用机理涉及第二个代谢途径导致β-d-2-Deoxy-2-Fluoro-2-C -甲基尿苷5-三磷酸丙型肝炎病毒RNA依赖性RNA聚合酶的有效抑制剂
7. The Mechanism of Action of β-d-2′-Deoxy-2′-Fluoro-2′-C-Methylcytidine Involves a Second Metabolic Pathway Leading to β-d-2′-Deoxy-2′-Fluoro-2′-C-Methyluridine 5′-Triphosphate, a Potent Inhibitor of the Hepatitis C Virus RNA-Dependent RNA Polymerase▿ [O] . Murakami, Eisuke, Niu, Congrong, Bao, Haiying, 2007

机译：β-d-2'-Deoxy-2'-Fluoro-2'-C-甲基胞苷的作用机理涉及第二个代谢途径，导致β-d-2'-Deoxy-2'-Fluoro-2'-C -甲基尿苷5'-三磷酸，一种丙型肝炎病毒RNA依赖性RNA聚合酶的有效抑制剂
8. Synthesis of Nucleoside Analogues with Potential Antiviral Activity against Negative Strand RNA Virus Targets. [R] . Walker, R. T. 1989

机译：具有抗负链RNa病毒靶标的潜在抗病毒活性的核苷类似物的合成。

Synthesis and antiviral activity of 2'-deoxy-2'-fluoro-2'-C-methyl purine nucleosides as inhibitors of hepatitis C virus RNA replication.

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