Refining ventilatory treatment for acute lung injury and acute respiratory distress syndrome.

摘要

The optimal PEEP strategy, however, has remained unresolved. Evidence from animal studies suggested that higher PEEP (in the range of 10-15 cm H2O) could prevent VILI.12'13 Thus, many clinicians were surprised when the first large randomized clinical trial comparing higher levels of PEEP with lower levels of PEEP in patients with ALI and ARDS, the National Heart, Lung, and Blood Institute's ARDS Network Assessment of Low Tidal Volume and Elevated End-Expiratory Lung Volume to Obviate Lung Injury (ALVEOLI) study,14 was stopped for futility.