CETP genes, metabolic effects, and coronary disease risk.

摘要

The CETP genotype relationship to CHD risk reported by Thompson et al is similar to that reported in a meta-analysis that focused on the CETP TaqlB variants. The study by Thompson et al7 answers the call for a comprehensive analysis of the gene effects related to CETP, its metabolites, and CHD risk,11 and differs from previous analyses by including much more data, especially concerning the intermediate biomarkers related to CETP metabolism, and by providing information on CETP gene variants other than TaqlB. The authors also report that CETP variants are common and the alleles they investigate affect at least half of the population.