Suitability of fetal tissues from spontaneous abortions and from ectopic pregnancies for transplantation. Human Fetal Tissue Working Group.

摘要

OBJECTIVE--To assess the potential availability and utility of fetal tissues obtained from spontaneous abortions and from ectopic pregnancies for human transplantation therapy. DESIGN--Tissue collection and analysis by personnel skilled in tissue banking. SETTING--Procurement programs in five tissue banks located in diverse geographical areas that are funded by the National Institutes of Health. PATIENTS--All women entering obstetric clinics during 1993 who consented to participate in the study. INTERVENTIONS--None. MAIN OUTCOME MEASURES--Evaluation of the products of conception by standard developmental, histological, microbiological, and cytogenetic criteria. RESULTS--From 22,235 obstetric admissions, 1250 spontaneously aborted embryos and 247 products of ectopic pregnancies were obtained. Of these, seven embryos (0.5%) were potentially useful for human transplantation therapy. CONCLUSION--Fetal tissues from spontaneous abortions and from ectopic pregnancies are quite limited as feasible sources for human transplantation therapy.