SYNTHESIS OF NALBUPHINE FROM ORIPAVINE VIA N-DEMETHYLATION OF N-CYCLOBUTYLMETHYL ORIPAVINE

Ales Machara; D. Phillip Cox; Tomas Hudlicky

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SYNTHESIS OF NALBUPHINE FROM ORIPAVINE VIA N-DEMETHYLATION OF N-CYCLOBUTYLMETHYL ORIPAVINE

机译：通过N-环戊基甲基甲乙胺的N-二甲基化反应从甲乙胺合成萘丁碱

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摘要

A short synthesis of nalbuphine from oripavine is reported via N-demethylation of N-cyclobutylmethyloripavine ammonium bromide.

机译：据报道，通过N-环丁基甲基欧pa藤溴化铵的N-去甲基化作用，可以从奥利巴韦合成纳布啡。

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《Heterocycles: An International Journal for Reviews and Communications in Heterocyclic Chemistry》 |2012年第1期|共9页
作者
Ales Machara; D. Phillip Cox; Tomas Hudlicky;
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正文语种 eng
中图分类化学;
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1. SYNTHESIS OF NALBUPHINE FROM ORIPAVINE VIA N-DEMETHYLATION OF N-CYCLOBUTYLMETHYL ORIPAVINE [J] . Ales Machara, D. Phillip Cox, Tomas Hudlicky Heterocycles: An International Journal for Reviews and Communications in Heterocyclic Chemistry . 2012,第1期

机译：通过N-环戊基甲基甲乙胺的N-二甲基化反应从甲乙胺合成萘丁碱
2. Synthesis of buprenorphine from oripavine via N-demethylation of oripavine quaternary salts [J] . Werner L., MacHara A., Adams D.R., The Journal of Organic Chemistry . 2011,第11期

机译：通过甲壳素季盐的N-去甲基化从甲壳素合成丁丙诺啡
3. Improved Synthesis of BuprenorpMne from Thebaiee and/or Oripavine via Palladium-Catalyzed N-Demethylation/Acylation aed/or Concomitant O-Demethylation [J] . Ales Machara, Lukas Werner, Mary Ann Endoma-Arias Advanced synthesis & catalysis . 2012,第4期

机译：通过钯催化的N-去甲基化/酰化和/或伴随的O-去甲基化，由Thebaiee和/或Oripavine改进丁丙诺普烯的合成
4. Levels of 5-HydraxyindoI Acetic Acid and Lipid Peroxidation In Brain after Administration of Marijuana and Nalbuphine in Male and Female Rat [C] . David Calderon Guzman1, Norma Labra Ruiz1, Ernestina Hernandez Garda2 and Hugo Juarez Olgum Western Pharmacology Society . 2010

机译：雄性和雌性大鼠大麻和纳丙酮脑后脑后脑血液过氧化水平
5. STEADY-STATE KINETICS AND MECHANISTIC STUDIES OF PEROXIDASE-CATALYZED N-DEMETHYLATION REACTIONS. [D] . KEDDERIS, GREGORY LEO. 1982

机译：过氧化物酶催化的N-二甲基化反应的稳态动力学和机理研究。
6. Pharmacological mechanisms underlying the antinociceptive and tolerance effects of the 614-bridged oripavine compound 030418 [O] . Quan Wen, Gang Yu, Yu-lei Li, 2011

机译：614桥联奥利巴韦胺030418的抗伤害感受和耐受作用的药理机制
7. Recent Advances in the Chemistry of Oripavine and Its Derivatives [O] . Hosztafi Sándor 2014

机译：Oripavine及其衍生物的化学研究进展

SYNTHESIS OF NALBUPHINE FROM ORIPAVINE VIA N-DEMETHYLATION OF N-CYCLOBUTYLMETHYL ORIPAVINE

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