Recent advances in the total synthesis of xanthanolide/dinorxanthanolide sesquiterpenoids are described. This family of natural products can be divided into two structural classes according to the stereochemistry at C8 of the basic carbon framework, the oxabicyclo[5.3.0]decene core, i.e., the cis- and trans-fused γ-butyrolactone series. This article reviews the successful total syntheses of the five natural products, 8-epi-xanthatin (1) and sundiversifolide (2) (the cis-series), and 11a,13-dihydroxanthatin (3), xanthatin (4) and diversifolide (5) (the trans-stries).
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