SYNTHESIS, FUNGICIDAL AND ANTIBACTERIAL ACTIVITY OF NEW PYRIDAZINE DERIVATIVES

摘要

Compounds 1-3 were obtained in the reaction of 3,6-dichloro-pyridazines with phenylacetonitriles in the biphasic system - DMSO / 50% NaOH. The chlorine atom was replaced with cycloalkylamino (4 -13) and hydrazinyl (23, 24) moiety. These last compounds were condensed with aldehydes (25 - 34). Pyridazynylphenylacetonitriles were converted into amides 14 -18 and thioamides 19 - 22. In compounds 2, 3 the chlorine atom was replaced with thiophenyl (37,38) and in compound 1 with thioethyl and thiophenyl (35,36) functional groups. In the reactions of compounds 1, 2 with ammonium polysulfide thioamides with thiol group (39, 40) and chlorine atom (41, 42) were obtained. Compounds 1 - 17,19 -43 were screened for antibacterial and fungicidal activities.