Novel synthesis and antibacterial activity of some pyridazine derivatives

摘要

Various pyridazin-3(2H)-ones, 3-chloropyridazines and pyridazin-3 (2H)-thiones were synthesized and treated with the sulpha drug (knowing by sulphamethoxazole). All the new compounds were evaluated for their antibacterial activity. They showed significant antibacterial activity against Staphylococcus aureus and Bacillus subtilis (Gram + ve) and E. coli, Pseudomonas aeruginosa and Yersinia enterocolitica (Gram - ve) bacteria by agar plate diffusion method.All Proposed structures were confirmed by IR, H-1 NMR, Mass spectra and Elemental analysis.