A new synthesis of substituted 2,5-dihydro[b]-oxepines

摘要

Based on Claisen rearrangement, Baeyer-Villiger oxidation, and ring-closing metathesis (RCM), a series of substituted 2,5-dihydrobenzo [b]-oxepines were synthesized from isovanillin in good over-all yields. Other appropriate substituted 2,5-dihydrobenzo[b] oxepines prepared from corresponding phenol derivatives were also described.